If you have any reason to suspect your pet has ingested something toxic, please contact your veterinarian or the ASPCA Animal Poison Control Center 24-hour hotline at (888) 426-4435.
Generic Name: Paroxetine
Brand Names: Paxil, Paxil CR
Paroxetine, a selective serotonin receptor inhibitor (SSRI), is commonly prescribed to treat depression in human medical practice. It is also used in veterinary practice to treat a wide range of behavioral issues. However, paroxetine can be toxic to your pet if ingested in significant quantities.
It is important to realize that, even at therapeutic doses, your pet may show signs of fatigue, excitation, nervousness, or loss of appetite.
Please note that other SSRIs (such as citalopram, escitalopram, fluoxetine, and sertraline) carry similar toxicity risks.
Signs and symptoms of toxicity: fatigue, agitation, tremors, increased saliva production, vomiting, loss of appetite or refusal to eat, seizures, aggression, weakness, diarrhea, decreased heart rate, and difficulty walking.
Doses of 1 mg/kg may cause mild sedation in dogs while signs of toxicity may be seen with doses of 10 mg/kg.
Pug, Boston Terrier, Poodle
Beagle, Scottish Terrier
Boxer, Cocker Spaniel
Retriever, German Shepherd
Great Dane, St. Bernard
|1 – 10 lbs.
(0.45 – 4.6 kg)
|11 – 25 lbs.
(5 – 11.4 kg)
|26 – 40 lbs.
(11.8 – 18.2 kg)
|41 – 70 lbs.
(18.6 – 31.8 kg)
|71 – 90 lbs.
(32.3 – 40.9 kg)
|91 – 110 lbs.
(41.4 – 50 kg)
|Paroxetine||> 4.4 mg||> 49 mg||> 117 mg||> 185 mg||> 322 mg||> 413 mg|
– Osweiler, G, et al. (2011). Blackwell’s five-minute veterinary consult clinical companion. Small Animal Toxicology. [Kindle version]. Retrieved from Amazon.com
– Wismer TA. Antidepressant drug overdoses in dogs. Vet Med 2000; 95:520-525.
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