If you have any reason to suspect your pet has ingested something toxic, please contact your veterinarian or one of the other resources listed:
ASPCA Animal Poison Control Center 24-hour hotline at (888) 426-4435
• Pet Poison Helpline® 24-hour animal poison control service at (855) 764-7661


Baclofen is a centrally-acting skeletal muscle relaxant used to control spasticity and pain in people with multiple sclerosis and spinal disorders. Used in dogs to treat urinary retention by reducing urethral resistance. Cats are particularly susceptible to toxicity. Even though baclofen is used in humans for muscle relaxation, it can be a severe toxin in pets and can lead to serious complications and potential death of the animal

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Signs and symptoms of toxicity: excessive barking or whining, vomiting, involuntary muscle movements, disorientation, increased saliva production, depression, weakness, seizures, very low body temperature, and refusal to stand up.

Toxic consumption: Doses of 1.3 mg/kg may be toxic and 8 mg/kg may cause death.

Dogs: Baclofen Toxic Consumption
Yorkie, Chihuahua
Pug, Boston Terrier, Poodle
Beagle, Scottish Terrier
Boxer, Cocker Spaniel
Labrador & Golden Retrievers, German Shepherd
Great Dane, St. Bernard
1 – 10 lbs.
(0.45 – 4.6 kg)
11 – 25 lbs.
(5 – 11.4 kg)
26 – 40 lbs.
(11.8 – 18.2 kg)
41 – 70 lbs.
(18.6 – 31.8 kg)
71 – 90 lbs.
(32.3 – 40.9 kg)
91 – 110 lbs.
(41.4 – 50 kg)
chihuahua pug beagle cocker spaniel golden retriever great dane
> 0.5 mg > 6.4 mg > 15 mg > 24 mg > 41 mg > 53 mg
Cats: Baclofen Toxic Consumption
Most Cats Large Cats
1 – 10 lbs.
(0.45 – 4.6 kg)
11 – 25 lbs.
(5 – 11.4 kg)
cat1 fat cat
> 0.5 mg > 6.4 mg

– Hecht DV, Allenspach K. Presumptive baclofen intoxication in a dog. J Vet Emerg Crit Care 1998; 8:49-54.
– Osweiler, G, et al. (2011). Blackwell’s five-minute veterinary consult clinical companion. Small Animal Toxicology. [Kindle version]. Retrieved from Amazon.com

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