If you have any reason to suspect your pet has ingested something toxic, please contact your veterinarian or one of the other resources* listed:
• ASPCA Animal Poison Control Center 24-hour hotline at (888) 426-4435
• Pet Poison Helpline® 24-hour animal poison control service at (855) 764-7661
*The resources listed above are not affiliated with the American College of Veterinary Pharmacists (ACVP), and they may charge a consultation fee. ACVP provides this referral information solely as a public service and does not receive any compensation from these organizations.
Baclofen
Baclofen is a centrally-acting skeletal muscle relaxant used to control spasticity and pain in people with multiple sclerosis and spinal disorders. Used in dogs to treat urinary retention by reducing urethral resistance. Cats are particularly susceptible to toxicity. Even though baclofen is used in humans for muscle relaxation, it can be a severe toxin in pets and can lead to serious complications and potential death of the animal
Signs and symptoms of toxicity: excessive barking or whining, vomiting, involuntary muscle movements, disorientation, increased saliva production, depression, weakness, seizures, very low body temperature, and refusal to stand up.
Toxic consumption: Doses of 1.3 mg/kg may be toxic and 8 mg/kg may cause death.
| X-Small Yorkie, Chihuahua |
Small Pug, Boston Terrier, Poodle |
Medium Beagle, Scottish Terrier |
Large Boxer, Cocker Spaniel |
X-Large Labrador & Golden Retrievers, German Shepherd |
XX-Large Great Dane, St. Bernard |
| 1 – 10 lbs. (0.45 – 4.6 kg) |
11 – 25 lbs. (5 – 11.4 kg) |
26 – 40 lbs. (11.8 – 18.2 kg) |
41 – 70 lbs. (18.6 – 31.8 kg) |
71 – 90 lbs. (32.3 – 40.9 kg) |
91 – 110 lbs. (41.4 – 50 kg) |
 |
 |
 |
 |
 |
 |
| > 0.5 mg | > 6.4 mg | > 15 mg | > 24 mg | > 41 mg | > 53 mg |
| Most Cats | Large Cats |
| 1 – 10 lbs. (0.45 – 4.6 kg) |
11 – 25 lbs. (5 – 11.4 kg) |
 |
 |
| > 0.5 mg | > 6.4 mg |
References:
– Hecht DV, Allenspach K. Presumptive baclofen intoxication in a dog. J Vet Emerg Crit Care 1998; 8:49-54.
– Osweiler, G, et al. (2011). Blackwell’s five-minute veterinary consult clinical companion. Small Animal Toxicology. [Kindle version]. Retrieved from Amazon.com
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