Dextromethorphan

Dextromethorphan (DMX) is a popular ingredient in many OTC antitussives, including Delsym and Robitussin-DM. These products help reduce coughing in those with respiratory infections and similar illness.

While dextromethorphan is sometimes used in veterinary practice (to treat repetitive behavior in dogs), it can be toxic if accidentally ingested by your pet.

Note that DMX can be found in OTC cough and cold medications along with other ingredients. If your pet has ingested any medication it is important to determine all ingredients in order to assess the risk of toxicity.

Signs and symptoms of toxicity: Involuntary muscle movements are common. Other signs of toxicity may include sedation, agitation, tremors, seizures, changes in heart rate (faster or slower), and increased body temperature. Effects from intoxication may slowly appear over several hours.

Toxic consumption: There is no established toxic threshold for pet consumption. In practice, the recommended dose for dogs is 2 mg/kg (0.9 mg/lb). Anything above this amount (listed below for reference purposes) may be considered toxic and should be reported immediately.

Dogs: Dextromethorphan Potentially Toxic Consumption
X-Small Yorkie, Chihuahua	Small Pug, Boston Terrier, Poodle	Medium Beagle, Scottish Terrier	Large Boxer, Cocker Spaniel	X-Large Retriever, German Shepherd	XX-Large Great Dane, St. Bernard
1 – 10 lbs. (0.45 – 4.6 kg)	11 – 25 lbs. (5 – 11.4 kg)	26 – 40 lbs. (11.8 – 18.2 kg)	41 – 70 lbs. (18.6 – 31.8 kg)	71 – 90 lbs. (32.3 – 40.9 kg)	91 – 110 lbs. (41.4 – 50 kg)
> 0.9 mg	> 10 mg	> 23.6 mg	> 37.2 mg	> 64.6 mg	> 82.8 mg

References:
– Osweiler, G, et al. (2011). Blackwell’s five-minute veterinary consult clinical companion. Small Animal Toxicology. [Kindle version]. Retrieved from Amazon.com
– Papich MG. Toxicoses from over-the-counter human drugs. Vet Clin North Am Small Anim Pract 1990; 20(2):431-451.