Project Description

If you have any reason to suspect your pet has ingested something toxic, please contact your veterinarian or the ASPCA Animal Poison Control Center 24-hour hotline at (888) 426-4435.


Generic Name: carprofen
Brand Name: Rimadyl

While carprofen, an NSAID, is approved for use to treat pain and inflammation in some animals, chronic use may cause toxicity. It is important to discontinue use of prescribed NSAIDs when your veterinarian tells you to do so. Toxicity can also occur if you pet consumes more medication than prescribed.

It is important to note that other veterinary NSAIDs (such as deracoxib, firocoxib, ketoprofen, meloxicam and tepoxalin) carry similar toxicity risks.

Signs and symptoms of toxicity: vomiting, abdominal pain, melena (black, tarry stool), diarrhea. These signs may occur within an hour of ingestion. Weakness, involuntary muscle movements, and seizures may also occur and these are signs of severe toxicity.

More severe toxicity (GI perforation or renal failure) may not occur until 48-72 hours after ingestion. Signs of kidney damage include increased thirst, increased urination, loss of appetite or refusal to eat, fatigue, and vomiting.

Toxic consumption:
Doses greater than 5 times the therapeutic dose can result in toxicity.

In cats, acute or chronic doses of any medication may cause toxicity.

In dogs, signs of toxicity can be seen with doses of 22 mg/kg.

Long term use, even at therapeutic doses, can result in clinical signs of toxicity.

Dogs: Carprofen Toxic Consumption
Yorkie, Chihuahua
Pug, Boston Terrier, Poodle
Beagle, Scottish Terrier
Boxer, Cocker Spaniel
Labrador & Golden Retrievers, German Shepherd
Great Dane, St. Bernard
1 - 10 lbs.
(0.45 - 4.6 kg)
11 - 25 lbs.
(5 - 11.4 kg)
26 - 40 lbs.
(11.8 - 18.2 kg)
41 - 70 lbs.
(18.6 - 31.8 kg)
71 - 90 lbs.
(32.3 - 40.9 kg)
91 - 110 lbs.
(41.4 - 50 kg)
dog1 dog2 dog3 dog4 dog7 dog6
Carprofen > 9.5 mg > 109 mg > 259 mg > 409 mg > 710 mg > 910 mg

- Matthews KA. Nonsteroidal anti-inflammatory analgesics. Vet Clin North Am Small Anim Pract 2000; 30(4):783-804.
- Osweiler, G, et al. (2011). Blackwell’s five-minute veterinary consult clinical companion. Small Animal Toxicology. [Kindle version]. Retrieved from