Alpha Lipoic Acid, also known as ALA, is a human dietary supplement used in the management of diabetes. While more toxic in cats, ALA can be dangerous if ingested by any pet.

Signs and symptoms of toxicity: Toxicity may be seen within 30 minutes or it may take up to several hours to develop. Signs and symptoms of toxicity include low blood sugar, increased thirst and salivating, vomiting, difficulty walking, tremors, and seizures.

Toxic consumption: In cats the minimum toxic dose is 13 mg/kg (5.9 mg/lb). In dogs, 126 mg/kg (57 mg/lb) is considered the toxic threshold although fatal cases have been reported with ingestion of 100 mg/kg (45 mg/lb).

Dogs: ALA Toxic Consumption
X-Small Yorkie, Chihuahua	Small Pug, Boston Terrier, Poodle	Medium Beagle, Scottish Terrier	Large Boxer, Cocker Spaniel	X-Large Retriever, German Shepherd	XX-Large Great Dane, St. Bernard
1 – 10 lbs. (0.45 – 4.6 kg)	11 – 25 lbs. (5 – 11.4 kg)	26 – 40 lbs. (11.8 – 18.2 kg)	41 – 70 lbs. (18.6 – 31.8 kg)	71 – 90 lbs. (32.3 – 40.9 kg)	91 – 110 lbs. (41.4 – 50 kg)
> 45 mg	> 500 mg	> 1180 mg	> 1860 mg	> 3230 mg	> 4140 mg

Cats: ALA Toxic Consumption
Most Cats	Large Cats
1 – 10 lbs. (0.45 – 4.6 kg)	11 – 25 lbs. (5 – 11.4 kg)
> 5.8 mg	> 65 mg

References:
– Osweiler, G, et al. (2011). Blackwell’s five-minute veterinary consult clinical companion. Small Animal Toxicology. [Kindle version]. Retrieved from Amazon.com