Digoxin

Generic Name: digoxin
Brand Name: Lanoxin

Digoxin is used in both human and veterinary medicine to treat a variety of cardiac disease states including congestive heart failure (CHF) and atrial fibrillation. Cats are relatively more sensitive to digoxin toxicity than dogs.

Signs and symptoms of toxicity: Cardiac arrhythmias are common with high or toxic blood levels. Extracardiac clinical signs commonly include mild GI upset, refusal to eat, weight loss and diarrhea.

Please note that vomiting is an adverse effect of digoxin IV injection and is not necessarily a sign that toxicity has occurred.

Toxic consumption: In dogs, acute toxicity has been reported with IV administration of 0.177 mg/kg or more. Chronic therapy may also result in toxicity.

Dogs: Digoxin Toxic Consumption
X-Small Yorkie, Chihuahua	Small Pug, Boston Terrier, Poodle	Medium Beagle, Scottish Terrier	Large Boxer, Cocker Spaniel	X-Large Labrador & Golden Retrievers, German Shepherd	XX-Large Great Dane, St. Bernard
1 – 10 lbs. (0.45 – 4.6 kg)	11 – 25 lbs. (5 – 11.4 kg)	26 – 40 lbs. (11.8 – 18.2 kg)	41 – 70 lbs. (18.6 – 31.8 kg)	71 – 90 lbs. (32.3 – 40.9 kg)	91 – 110 lbs. (41.4 – 50 kg)
> 0.08 mg	> 0.8 mg	> 2 mg	> 3.2 mg	> 5.7 mg	> 7.3 mg

References:
– Digoxin. In: Plumb’s Veterinary Drugs. Tulsa (OK): Educational Concepts, L.L.C. [updated 1/14; accessed 8/27/15]. https://www.plumbsveterinarydrugs.com/#!/monograph/921
– Papich MG. Saunders Handbook of Veterinary Drugs: Small and Large Animal. 3rd ed. St. Louis, MS: Elsevier Saunders; 2011.