Project Description

Generic Name: hydrochlorothiazide
Brand Names: Aquazide H, Hydrocot, Microzide, Zide

With accidental ingestion of a diuretic medication, like hydrochlorothiazide, your pet is at risk for extreme dehydration and damage to critical organs. It is important to seek veterinary support immediately for rehydration with fluids.

If your pet is taking hydrochlorothiazide, watch for changes in appetite, thirst, or urination. If your animal refuses to eat or drink fluids, contact your veterinarian immediately.


It is important to note that other diuretics (such as mannitol, acetazolamide, furosemide, and spironolactone) carry similar toxicity risks.

Signs and symptoms of toxicity: Clinical signs of toxicity include depression, weakness, fatigue, excessive thirst, decreased urination, vomiting, abnormal heart beat, loss of appetite or refusal to eat.

Toxic consumption: There is no established toxic threshold for pet consumption. All incidents of accidental exposure should be reported immediately.

– Osweiler, G, et al. (2011). Blackwell’s five-minute veterinary consult clinical companion. Small Animal Toxicology. [Kindle version]. Retrieved from